Given the option, it is clear that people who use MDMA and other drugs will embrace harm reduction approaches, and support their development. Harm reduction is not a principle that policy makers will need to force upon people who use MDMA or other drugs in nightlife and party settings. Significant numbers of people not only like MDMA’s effects and are willing to take known risks (health and legal) to enjoy them, but they seem to prefer it to most available substitutes. Perhaps most obviously it demonstrates, yet again, the futility of putting enforcement, targeting either people who use or supply, at the forefront of the policy response to drugs. The EMCDDA also reported in 2019 that ‘transactions involving quantities of MDMA tablets buy ecstasy indicative of the middle level of the market account for more than double the revenue of sales of retail-level quantities